Detection of Nanoparticle Endocytosis Using Magneto-Photoacoustic Imaging

Authors

  • Min Qu,

    1. Department of Biomedical Engineering, University of Texas at Austin, 1 University Station C0800, Austin, TX 78712, USA
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  • Mohammad Mehrmohammadi,

    1. Department of Biomedical Engineering, University of Texas at Austin, 1 University Station C0800, Austin, TX 78712, USA
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  • Stanislav Emelianov

    Corresponding author
    1. Department of Biomedical Engineering, University of Texas at Austin, 1 University Station C0800, Austin, TX 78712, USA
    • Department of Biomedical Engineering, University of Texas at Austin, 1 University Station C0800, Austin, TX 78712, USA.
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Abstract

original image

The endocytosis of nanoparticles by cells is of significant interest in various biomedical applications, including drug delivery and targeted therapy. An approach is developed to noninvasively detect nanoparticle endocytosis by living cells using magneto-photoacoustic (MPA) imaging. Using macrophages, it is demonstrated that the nanoparticles endocytosed by cells generate significantly larger MPA signals than the same concentration of nanoparticles present in the vicinity of macrophages. Overall, MPA imaging can simultaneously detect both the delivery and cellular endocytosis of nanoparticles.

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