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Electrospun Fiber Template for Replica Molding of Microtopographical Neural Growth Guidance

Authors

  • Yingyi Liu,

    1. CAS Key lab for Biological Effects of Nanomaterials and Nanosafety, National Center for NanoScience and Technology, 11 Beiyitiao, ZhongGuanCun, Beijing 100190, China
    2. Graduate University of the Chinese Academy of Science 19A Yuquanlu, Beijing, 100049, China
    Current affiliation:
    1. These authors contributed equally to this work.
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  • Yi Sun,

    1. CAS Key lab for Biological Effects of Nanomaterials and Nanosafety, National Center for NanoScience and Technology, 11 Beiyitiao, ZhongGuanCun, Beijing 100190, China
    2. Graduate University of the Chinese Academy of Science 19A Yuquanlu, Beijing, 100049, China
    Current affiliation:
    1. These authors contributed equally to this work.
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  • Hao Yan,

    1. CAS Key lab for Biological Effects of Nanomaterials and Nanosafety, National Center for NanoScience and Technology, 11 Beiyitiao, ZhongGuanCun, Beijing 100190, China
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  • Xiyu Liu,

    1. CAS Key lab for Biological Effects of Nanomaterials and Nanosafety, National Center for NanoScience and Technology, 11 Beiyitiao, ZhongGuanCun, Beijing 100190, China
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  • Wei Zhang,

    Corresponding author
    1. CAS Key lab for Biological Effects of Nanomaterials and Nanosafety, National Center for NanoScience and Technology, 11 Beiyitiao, ZhongGuanCun, Beijing 100190, China
    • CAS Key lab for Biological Effects of Nanomaterials and Nanosafety, National Center for NanoScience and Technology, 11 Beiyitiao, ZhongGuanCun, Beijing 100190, China.
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  • Zhuo Wang,

    1. CAS Key lab for Biological Effects of Nanomaterials and Nanosafety, National Center for NanoScience and Technology, 11 Beiyitiao, ZhongGuanCun, Beijing 100190, China
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  • Xingyu Jiang

    Corresponding author
    1. CAS Key lab for Biological Effects of Nanomaterials and Nanosafety, National Center for NanoScience and Technology, 11 Beiyitiao, ZhongGuanCun, Beijing 100190, China
    • CAS Key lab for Biological Effects of Nanomaterials and Nanosafety, National Center for NanoScience and Technology, 11 Beiyitiao, ZhongGuanCun, Beijing 100190, China.
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Abstract

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A method for replica molding electrospun (ES) fibers on the surface of polydimethylsiloxane (PDMS) is developed for culturing and guiding of cells, instead of ES fibers. With this method, microgrooves and microstructures composed of microgrooves can be obtained. PDMS is integrated into the microfluidic chip as a substrate to successfully pattern and guide neurites on the PDMS surface with microgrooves.

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