Communication

Design and Self-Assembly of a Leucine-Enkephalin Analogue in Different Nanostructures: Application of Nanovesicles

  1. Pradyot Koley1,†,
  2. Anindita Gayen1,†,
  3. Michael G. B. Drew2,
  4. Chaitali Mukhopadhyay1,*,
  5. Animesh Pramanik1,*

Article first published online: 10 FEB 2012

DOI: 10.1002/smll.201101685

Issue

Small

Small

Volume 8, Issue 7, pages 984–990, April 10, 2012

Additional Information

How to Cite

Koley, P., Gayen, A., Drew, M. G. B., Mukhopadhyay, C. and Pramanik, A. (2012), Design and Self-Assembly of a Leucine-Enkephalin Analogue in Different Nanostructures: Application of Nanovesicles. Small, 8: 984–990. doi: 10.1002/smll.201101685

Author Information

  1. 1

    Department of Chemistry, University of Calcutta, 92, A. P. C. Road, Kolkata-700 009, India, Fax: +91 033 2351 9755

  2. 2

    School of Chemistry, The University of Reading, Whiteknights, Reading RG6 6AD, UK

  1. †

    P.K and A.G contributed equally to this work.

*Department of Chemistry, University of Calcutta, 92, A. P. C. Road, Kolkata-700 009, India, Fax: +91 033 2351 9755.

Publication History

  1. Issue published online: 4 APR 2012
  2. Article first published online: 10 FEB 2012
  3. Manuscript Revised: 1 NOV 2011
  4. Manuscript Received: 17 AUG 2011

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Keywords:

  • leucine-enkephalin;
  • nanostructures;
  • curcumin;
  • encapsulation;
  • responsive materials
Thumbnail image of graphical abstract

An opioid (leucine-enkephalin) conformational analogue forms diverse nanostructures such as vesicles, tubes, and organogels through self-assembly. The nanovesicles encapsulate the natural hydrophobic drug curcumin and allow the controlled release through cation-generated porogens in membrane mimetic solvent.

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