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Design and Self-Assembly of a Leucine-Enkephalin Analogue in Different Nanostructures: Application of Nanovesicles

Authors

  • Pradyot Koley,

    1. Department of Chemistry, University of Calcutta, 92, A. P. C. Road, Kolkata-700 009, India, Fax: +91 033 2351 9755
    Current affiliation:
    1. P.K and A.G contributed equally to this work.
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  • Anindita Gayen,

    1. Department of Chemistry, University of Calcutta, 92, A. P. C. Road, Kolkata-700 009, India, Fax: +91 033 2351 9755
    Current affiliation:
    1. P.K and A.G contributed equally to this work.
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  • Michael G. B. Drew,

    1. School of Chemistry, The University of Reading, Whiteknights, Reading RG6 6AD, UK
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  • Chaitali Mukhopadhyay,

    Corresponding author
    1. Department of Chemistry, University of Calcutta, 92, A. P. C. Road, Kolkata-700 009, India, Fax: +91 033 2351 9755
    • Department of Chemistry, University of Calcutta, 92, A. P. C. Road, Kolkata-700 009, India, Fax: +91 033 2351 9755.
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  • Animesh Pramanik

    Corresponding author
    1. Department of Chemistry, University of Calcutta, 92, A. P. C. Road, Kolkata-700 009, India, Fax: +91 033 2351 9755
    • Department of Chemistry, University of Calcutta, 92, A. P. C. Road, Kolkata-700 009, India, Fax: +91 033 2351 9755.
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Abstract

original image

An opioid (leucine-enkephalin) conformational analogue forms diverse nanostructures such as vesicles, tubes, and organogels through self-assembly. The nanovesicles encapsulate the natural hydrophobic drug curcumin and allow the controlled release through cation-generated porogens in membrane mimetic solvent.

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