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Magnetic-Nanoparticle-Doped Carbogenic Nanocomposite: An Effective Magnetic Resonance/Fluorescence Multimodal Imaging Probe

Authors

  • Sachchidanand Srivastava,

    1. Department of Chemistry, Indian Institute of Technology, Kanpur 208016, India
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  • Rishi Awasthi,

    1. Department of Radiodiagnosis, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow 226014, India
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  • Deepak Tripathi,

    1. Department of Immunology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow 226014, India
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  • Mohit K. Rai,

    1. Department of Immunology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow 226014, India
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  • Vikas Agarwal,

    1. Department of Immunology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow 226014, India
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  • Vinita Agrawal,

    1. Department of Pathology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow 226016, India
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  • Namdeo S. Gajbhiye,

    Corresponding author
    1. Department of Chemistry, Indian Institute of Technology, Kanpur 208016, India
    • Namdeo S. Gajbhiye, Department of Chemistry, Indian Institute of Technology, Kanpur 208016, India

      Rakesh K. Gupta, Department of Radiodiagnosis, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow 226014, India.

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  • Rakesh K. Gupta

    Corresponding author
    1. Department of Radiodiagnosis, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow 226014, India
    • Namdeo S. Gajbhiye, Department of Chemistry, Indian Institute of Technology, Kanpur 208016, India

      Rakesh K. Gupta, Department of Radiodiagnosis, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow 226014, India.

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Errata

This article is corrected by:

  1. Errata: Magnetic-Nanoparticle-Doped Carbogenic Nanocomposite: An Effective Magnetic Resonance/Fluorescence Multimodal Imaging Probe Volume 8, Issue 7, 961, Article first published online: 5 March 2012

Abstract

A novel and facile approach is developed to synthesize a magnetic nanoparticle (iron oxide)-doped carbogenic nanocomposite (IO-CNC) for magnetic resonance (MR)/fluorescence imaging applications. IO-CNC is synthesized by thermal decomposition of organic precursors in the presence of Fe3O4 nanoparticles with an average size of 6 nm. IO-CNC shows wavelength-tunable fluorescence properties with high quantum yield. Magnetic studies confirm the superparamagnetic nature of IO-CNC at room temperature. IO-CNC shows MR contrast behavior by affecting the proton relaxation phenomena. The measured longitudinal (r1) and transverse (r2) relaxivity values are 4.52 and 34.75 mM−1 s−1, respectively. No apparent cytotoxicity is observed and the nanocomposite shows a biocompatible nature. In vivo MR studies show both T1 and T2* contrast behavior of the nanocomposite. Fluorescence imaging indicates selective uptake of IO-CNC by macrophages in spleen.

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