Enhancing Surface Interactions with Colon Cancer Cells on a Transferrin-Conjugated 3D Nanostructured Substrate



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A transferrin-conjugated PEG-Fe3O4 nanostructured matrix is developed to explore cellular responses in terms of enhanced cell adhesion, specific interactions between ligands in the matrix and molecular receptors on the cell membrane, comparison of cell shapes on 2D and 3D surfaces, and effect of polymer architecture on cell adhesion. Integration of such advanced synthetic nanomaterials into a functionalized 3D matrix to control cell behavior on surfaces will have implications in nanomedicine.