Communication

Caged-Protein-Confined Bimetallic Structural Assemblies with Mimetic Peroxidase Activity

  1. Wei Zhang1,
  2. Xiangyou Liu1,
  3. Dominic Walsh2,
  4. Siyu Yao1,3,
  5. Yuan Kou1,
  6. Ding Ma1,*

Article first published online: 9 JUL 2012

DOI: 10.1002/smll.201102480

Issue

Small

Small

Volume 8, Issue 19, pages 2948–2953, October 8, 2012

Additional Information

How to Cite

Zhang, W., Liu, X., Walsh, D., Yao, S., Kou, Y. and Ma, D. (2012), Caged-Protein-Confined Bimetallic Structural Assemblies with Mimetic Peroxidase Activity. Small, 8: 2948–2953. doi: 10.1002/smll.201102480

Author Information

  1. 1

    Beijing National Laboratory for Molecular Sciences, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China

  2. 2

    Center for Organized Matter Chemistry, School of Chemistry, University of Bristol, Bristol, BS8 1TS, UK

  3. 3

    Center for Computational Science & Engineering, Peking University, Beijing, 100871, China

*Beijing National Laboratory for Molecular Sciences, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China.

Publication History

  1. Issue published online: 2 OCT 2012
  2. Article first published online: 9 JUL 2012
  3. Manuscript Received: 25 NOV 2012
  4. Manuscript Revised: 1 MAY 2012

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Keywords:

  • apoferritin;
  • confinement;
  • bimetallic structural ensembles;
  • mimetic peroxidase activity;
  • biosensors
Thumbnail image of graphical abstract

Protein-confined bimetallic structural ensembles with mimetic peroxidase activity are constructed. The oxidation reaction of 3,3,5,5-tetramethylbenzidine (TMB) with H2O2 is chosen to detect catalytic activity using UV–vis spectroscopy. The artificial enzyme is coupled with oxidase to build a dual-enzyme sensor system for the detection of biomolecules.

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