Advertisement

Caged-Protein-Confined Bimetallic Structural Assemblies with Mimetic Peroxidase Activity

Authors

  • Wei Zhang,

    1. Beijing National Laboratory for Molecular Sciences, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China
    Search for more papers by this author
  • Xiangyou Liu,

    1. Beijing National Laboratory for Molecular Sciences, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China
    Search for more papers by this author
  • Dominic Walsh,

    1. Center for Organized Matter Chemistry, School of Chemistry, University of Bristol, Bristol, BS8 1TS, UK
    Search for more papers by this author
  • Siyu Yao,

    1. Beijing National Laboratory for Molecular Sciences, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China
    2. Center for Computational Science & Engineering, Peking University, Beijing, 100871, China
    Search for more papers by this author
  • Yuan Kou,

    1. Beijing National Laboratory for Molecular Sciences, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China
    Search for more papers by this author
  • Ding Ma

    Corresponding author
    1. Beijing National Laboratory for Molecular Sciences, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China
    • Beijing National Laboratory for Molecular Sciences, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China.
    Search for more papers by this author

Abstract

original image

Protein-confined bimetallic structural ensembles with mimetic peroxidase activity are constructed. The oxidation reaction of 3,3,5,5-tetramethylbenzidine (TMB) with H2O2 is chosen to detect catalytic activity using UV–vis spectroscopy. The artificial enzyme is coupled with oxidase to build a dual-enzyme sensor system for the detection of biomolecules.

Ancillary