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Keywords:

  • drug delivery;
  • holmium;
  • imaging;
  • nanoparticle;
  • ovarian cancer
Thumbnail image of graphical abstract

Nanoparticles containing stable holmium (165Ho) are prepared by nanotemplate engineering and subsequently irradiated in a neutron flux to yield 166Ho, a beta-emitting radiotherapeutic isotope. After intraperitoneal injection to mice bearing SKOV-3 ovarian tumors, significant tumor accumulation of the 166Ho-nanoparticles is observed by SPECT imaging indicating the potential of these neutron activatable nanoparticles for internal radiation therapy of ovarian cancer metastases.