Communication

Sensitive Detection of Spores Using Volume-Amplified Magnetic Nanobeads

  1. Teresa Zardán Gómez de la Torre1,†,
  2. Rongqin Ke2,†,
  3. Anja Mezger2,
  4. Peter Svedlindh3,
  5. Maria Strømme1,*,
  6. Mats Nilsson2,*

Article first published online: 19 APR 2012

DOI: 10.1002/smll.201102632

Issue

Small

Small

Volume 8, Issue 14, pages 2174–2177, July 23, 2012

Additional Information

How to Cite

Gómez de la Torre, T. Z., Ke, R., Mezger, A., Svedlindh, P., Strømme, M. and Nilsson, M. (2012), Sensitive Detection of Spores Using Volume-Amplified Magnetic Nanobeads. Small, 8: 2174–2177. doi: 10.1002/smll.201102632

Author Information

  1. 1

    Department of Engineering Sciences, Division for Nanotechnology and Functional Materials, The Ångström Laboratory, Uppsala University, Box 534, 75121 Uppsala, Sweden

  2. 2

    Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Rudbeck Laboratory, Uppsala University, 75185 Uppsala, Sweden

  3. 3

    Department of Engineering Sciences, Division for Solid State Physics, The Ångström Laboratory, Uppsala University, Box 534, 75121 Uppsala, Sweden

  1. †

    These authors contributed equally to this work.

*Department of Engineering Sciences, Division for Nanotechnology and Functional Materials, The Ångström Laboratory, Uppsala University, Box 534, 75121 Uppsala, Sweden

Publication History

  1. Issue published online: 13 JUL 2012
  2. Article first published online: 19 APR 2012
  3. Manuscript Revised: 15 FEB 2012
  4. Manuscript Received: 12 JAN 2012

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Keywords:

  • biosensors;
  • immunoassays;
  • magnetic particles;
  • spores;
  • nanobeads
Thumbnail image of graphical abstract

A magnetic-nanobead-based, substrate-free method for the sensitive detection of spores in an immunoassay format is presented. The method is shown to detect Bacillus globigii spores, the non-pathogenic simulant of Bacillus anthracis, with a limit-of-detection of 50 spores with a reaction time of 135 min. The study shows the versatility of magnetic nanobeads for detection of biological molecules other than DNA.

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