Frontispiece

Drug Delivery: Vaults Engineered for Hydrophobic Drug Delivery (Small 10/2011)

  1. Daniel C. Buehler1,
  2. Daniel B. Toso2,
  3. Valerie A. Kickhoefer1,
  4. Z. Hong Zhou2,3,
  5. Leonard H. Rome1,3,*

Article first published online: 19 MAY 2011

DOI: 10.1002/smll.201190037

Issue

Small

Small

Special Issue: Nanotechnology with Soft Matter

Volume 7, Issue 10, page 1431, May 23, 2011

Additional Information

How to Cite

Buehler, D. C., Toso, D. B., Kickhoefer, V. A., Zhou, Z. H. and Rome, L. H. (2011), Drug Delivery: Vaults Engineered for Hydrophobic Drug Delivery (Small 10/2011). Small, 7: 1431. doi: 10.1002/smll.201190037

Author Information

  1. 1

    Department of Biological Chemistry, David Geffen School of Medicine, 615 Charles E. Young Dr. South, University of California, Los Angeles, CA 90095, USA

  2. 2

    Department of Microbiology, Immunology & Molecular Genetics, and Biomedical Engineering Program, 609 Charles E. Young Dr. South, University of California, Los Angeles, California 90095, USA

  3. 3

    California Nanosystems Institute, University of California, Los Angeles, California 90095, USA

*Department of Biological Chemistry, David Geffen School of Medicine, 615 Charles E. Young Dr. South, University of California, Los Angeles, CA 90095, USA.

Publication History

  1. Issue published online: 19 MAY 2011
  2. Article first published online: 19 MAY 2011

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Keywords:

  • vaults;
  • nanoparticles;
  • nanodisk;
  • all-trans retinoic acid;
  • drug delivery
Thumbnail image of graphical abstract

The frontispiece of the Full Papers section (right) shows a single-particle electron microscope tomography reconstruction, which reveals that a fully assembled drug-loaded nanodisk (red) can be packaged into the vault lumen (green) as a viable method for vault-mediated drug delivery. The electron micrograph in the background shows negatively stained vaults containing nanodisks. For more information, please read the Full Paper “Vaults Engineered for Hydrophobic Drug Delivery” by L. H. Rome and co-workers, beginning on page 1431.

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