Advertisement

Cancer Therapy: Single-Cell-Level Microplasma Cancer Therapy (Small 16/2011)

Authors

  • Jae Young Kim,

    1. Holcombe Department of Electrical and Computer Engineering, Center for Optical Materials Science and Engineering Technologies (COMSET), Clemson University, Clemson, SC 29634, USA
    Search for more papers by this author
  • Yanzhang Wei,

    1. Department of Biological Sciences, Clemson University Biomedical Institute, Clemson University, Greenville, SC 29605, USA
    Search for more papers by this author
  • Jinhua Li,

    1. Department of Biological Sciences, Clemson University Biomedical Institute, Clemson University, Greenville, SC 29605, USA
    Search for more papers by this author
  • Paul Foy,

    1. School of Materials Science and Engineering, Center for Optical Materials Science and Engineering Technologies (COMSET), Clemson University, Clemson, SC 29634, USA
    Search for more papers by this author
  • Thomas Hawkins,

    1. School of Materials Science and Engineering, Center for Optical Materials Science and Engineering Technologies (COMSET), Clemson University, Clemson, SC 29634, USA
    Search for more papers by this author
  • John Ballato,

    1. School of Materials Science and Engineering, Center for Optical Materials Science and Engineering Technologies (COMSET), Clemson University, Clemson, SC 29634, USA
    Search for more papers by this author
  • Sung-O Kim

    Corresponding author
    1. Holcombe Department of Electrical and Computer Engineering, Center for Optical Materials Science and Engineering Technologies (COMSET), Clemson University, Clemson, SC 29634, USA
    • Holcombe Department of Electrical and Computer Engineering, Center for Optical Materials Science and Engineering Technologies (COMSET), Clemson University, Clemson, SC 29634, USA.
    Search for more papers by this author

Abstract

original image

The image shows the apoptotic response in B16F0 tumor cells induced by a 15 μm hollow-core optical fiber microplasma jet assay using the TUNEL assay, which detects DNA nicks–an important cell apoptotic indicator. Apoptotic tumor cells treated by the plasma device show DNA nicks, and their nuclei are dyed to a bright color by the imaging assay kit, whereas no response was found in untreated cells. A well-defined boundary between plasma-treated and nontreated areas can be observed. This work enables new directed cancer therapies based on a highly flexible and precise hollow, optical-fiber-based microplasma cancer endoscope, and it offers unique advantages to understanding plasmainduced tumor cell apoptosis.

Ancillary