Communication

Small Molecule–Gold Nanorod Conjugates Selectively Target and Induce Macrophage Cytotoxicity towards Breast Cancer Cells

  1. Erik C. Dreaden1,
  2. Sandra C. Mwakwari2,
  3. Lauren A. Austin1,
  4. Matthew J. Kieffer1,
  5. Adegboyega K. Oyelere2,*,
  6. Mostafa A. El-Sayed1,*

Article first published online: 6 JUL 2012

DOI: 10.1002/smll.201200333

Issue

Small

Small

Volume 8, Issue 18, pages 2819–2822, September 24, 2012

Additional Information

How to Cite

Dreaden, E. C., Mwakwari, S. C., Austin, L. A., Kieffer, M. J., Oyelere, A. K. and El-Sayed, M. A. (2012), Small Molecule–Gold Nanorod Conjugates Selectively Target and Induce Macrophage Cytotoxicity towards Breast Cancer Cells. Small, 8: 2819–2822. doi: 10.1002/smll.201200333

Author Information

  1. 1

    Laser Dynamics Laboratory, Department of Chemistry and Biochemistry, Georgia Institute of Technology, 901 Atlantic Drive NW, Atlanta, GA 30332-0400, USA

  2. 2

    Petit Institute for Bioengineering and Biosciences, Department of Chemistry and Biochemistry, Georgia Institute of Technology, 315 Ferst Drive NW, Atlanta, GA 30332-0230, USA

*Petit Institute for Bioengineering and Biosciences, Department of Chemistry and Biochemistry, Georgia Institute of Technology, 315 Ferst Drive NW, Atlanta, GA 30332-0230, USA

Publication History

  1. Issue published online: 17 SEP 2012
  2. Article first published online: 6 JUL 2012
  3. Manuscript Received: 11 FEB 2012

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Keywords:

  • nanomedicine;
  • immunomodulation;
  • photothermal therapy;
  • immunostimulation;
  • nanotechnology
Thumbnail image of graphical abstract

Gold nanoparticles are known to activate anti-tumor potential in macrophage immune cells; however, the subsequent effects of these cells on others nearby are poorly understood. A novel gold–nanoparticle conjugate that selectively targets and induces cytotoxic activity of tumor-associated macrophages towards breast cancer cells in co-culture is synthesized. These constructs are promising new tools for studying fundamental biological interactions with nanoscale materials and candidates for emerging macrophage-mediated delivery applications.

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