Small Molecule–Gold Nanorod Conjugates Selectively Target and Induce Macrophage Cytotoxicity towards Breast Cancer Cells

Authors

  • Erik C. Dreaden,

    1. Laser Dynamics Laboratory, Department of Chemistry and Biochemistry, Georgia Institute of Technology, 901 Atlantic Drive NW, Atlanta, GA 30332-0400, USA
    Search for more papers by this author
  • Sandra C. Mwakwari,

    1. Petit Institute for Bioengineering and Biosciences, Department of Chemistry and Biochemistry, Georgia Institute of Technology, 315 Ferst Drive NW, Atlanta, GA 30332-0230, USA
    Search for more papers by this author
  • Lauren A. Austin,

    1. Laser Dynamics Laboratory, Department of Chemistry and Biochemistry, Georgia Institute of Technology, 901 Atlantic Drive NW, Atlanta, GA 30332-0400, USA
    Search for more papers by this author
  • Matthew J. Kieffer,

    1. Laser Dynamics Laboratory, Department of Chemistry and Biochemistry, Georgia Institute of Technology, 901 Atlantic Drive NW, Atlanta, GA 30332-0400, USA
    Search for more papers by this author
  • Adegboyega K. Oyelere,

    Corresponding author
    1. Petit Institute for Bioengineering and Biosciences, Department of Chemistry and Biochemistry, Georgia Institute of Technology, 315 Ferst Drive NW, Atlanta, GA 30332-0230, USA
    • Petit Institute for Bioengineering and Biosciences, Department of Chemistry and Biochemistry, Georgia Institute of Technology, 315 Ferst Drive NW, Atlanta, GA 30332-0230, USA
    Search for more papers by this author
  • Mostafa A. El-Sayed

    Corresponding author
    1. Laser Dynamics Laboratory, Department of Chemistry and Biochemistry, Georgia Institute of Technology, 901 Atlantic Drive NW, Atlanta, GA 30332-0400, USA
    • Laser Dynamics Laboratory, Department of Chemistry and Biochemistry, Georgia Institute of Technology, 901 Atlantic Drive NW, Atlanta, GA 30332-0400, USA.
    Search for more papers by this author

Abstract

original image

Gold nanoparticles are known to activate anti-tumor potential in macrophage immune cells; however, the subsequent effects of these cells on others nearby are poorly understood. A novel gold–nanoparticle conjugate that selectively targets and induces cytotoxic activity of tumor-associated macrophages towards breast cancer cells in co-culture is synthesized. These constructs are promising new tools for studying fundamental biological interactions with nanoscale materials and candidates for emerging macrophage-mediated delivery applications.

Ancillary