Protein–Polymer Hybrid Nanoparticles for Drug Delivery

Authors

  • Jun Ge,

    1. Department of Chemistry, Stanford University, Stanford, CA 94305-5080, USA
    2. Department of Chemical Engineering, Tsinghua University, Beijing 100084, China
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  • Evgenios Neofytou,

    1. Department of Cardiothoracic Surgery, Falk Cardiovascular Research Center, Stanford University School of Medicine, Stanford, CA 94305-5407, USA
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  • Jiandu Lei,

    1. Department of Chemistry, Stanford University, Stanford, CA 94305-5080, USA
    2. National Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences Beijing 100190, China
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  • Ramin E. Beygui,

    1. Department of Cardiothoracic Surgery, Falk Cardiovascular Research Center, Stanford University School of Medicine, Stanford, CA 94305-5407, USA
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  • Richard N. Zare

    Corresponding author
    1. Department of Chemistry, Stanford University, Stanford, CA 94305-5080, USA
    • Department of Chemistry, Stanford University, Stanford, CA 94305-5080, USA.
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Abstract

original image

Amphiphilic bovine serum albumin-poly(methyl methacrylate) conjugate forms nanoparticles with the uniform size of ∼100 nm by self-assembling. Loaded with the hydrophobic anti-tumor drug camptothecin, the nanoparticle efficiently delivers drugs into cancer cells, and thus inhibits ∼79% of tumor growth in animals compared with free drug.

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