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Dual Imaging and Photoactivated Nanoprobe for Controlled Cell Tracking

Authors

  • Sarit S. Agasti,

    1. Center for Systems Biology, Massachusetts General Hospital/Harvard, Medical School, 185 Cambridge St., Boston, MA 02114, USA
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  • Rainer H. Kohler,

    1. Center for Systems Biology, Massachusetts General Hospital/Harvard, Medical School, 185 Cambridge St., Boston, MA 02114, USA
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  • Monty Liong,

    1. Center for Systems Biology, Massachusetts General Hospital/Harvard, Medical School, 185 Cambridge St., Boston, MA 02114, USA
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  • Vanessa M. Peterson,

    1. Center for Systems Biology, Massachusetts General Hospital/Harvard, Medical School, 185 Cambridge St., Boston, MA 02114, USA
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  • Hakho Lee,

    1. Center for Systems Biology, Massachusetts General Hospital/Harvard, Medical School, 185 Cambridge St., Boston, MA 02114, USA
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  • Ralph Weissleder

    Corresponding author
    1. Center for Systems Biology, Massachusetts General Hospital/Harvard, Medical School, 185 Cambridge St., Boston, MA 02114, USA
    2. Department of Systems Biology, Harvard Medical School, 200 Longwood Ave., Alpert 536, Boston, MA 02115, USA
    • Center for Systems Biology, Massachusetts General Hospital/Harvard, Medical School, 185 Cambridge St., Boston, MA 02114, USA.
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Abstract

original image

A photoactivated nanoprobe for cell labeling and tracking is demonstrated. The nanoprobe enables all targeted cells to be imaged (at 680 nm) as well as specific cells to be photoactivated using 405 nm light. Photoactivated cells can then be tracked (at 525 nm) spatiotemporally in a separate channel over prolonged periods.

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