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Gold Nanoparticles Elevate Plasma Testosterone Levels in Male Mice without Affecting Fertility

Authors

  • Wen-Qing Li,

    1. Hefei National Laboratory for Physical Sciences at the Microscale and School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230027, PR China
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  • Feng Wang,

    1. Hefei National Laboratory for Physical Sciences at the Microscale and School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230027, PR China
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  • Zhi-Min Liu,

    1. Hefei National Laboratory for Physical Sciences at the Microscale and School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230027, PR China
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  • Yu-Cai Wang,

    1. Hefei National Laboratory for Physical Sciences at the Microscale and School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230027, PR China
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  • Jun Wang,

    Corresponding author
    1. Hefei National Laboratory for Physical Sciences at the Microscale and School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230027, PR China
    • Hefei National Laboratory for Physical Sciences at the Microscale and School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230027, PR China.
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  • Fei Sun

    Corresponding author
    1. Hefei National Laboratory for Physical Sciences at the Microscale and School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230027, PR China
    • Hefei National Laboratory for Physical Sciences at the Microscale and School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230027, PR China.
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Abstract

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ω-Methoxy and ω-aminoethyl poly(ethylene glycol)-modified 14-nm gold nanoparticles can accumulate in mouse testes, pass through the blood–testis barrier, and enter germ cells. Furthermore, PEG–NH2@AuNP accumulate more easier in the testes and increase plasma T levels. However, these two gold nanoparticle types have no effect on male fertility, fetal survival, or fetal development.

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