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Keywords:

  • assays;
  • biophysics;
  • DNA-protein interactions;
  • microarrays;
  • molecular mechanics
Thumbnail image of graphical abstract

The binding force chip (BiFo-Chip) allows the quantification of DNA–protein interactions. It employs arrays of molecular force probes. Each molecular force probe functions comparable to a balance, which is influenced by the binding of a protein to one of the two DNA duplexes. The BiFo-chip is easy to operate, requires only a quantitative fluorescence microscope and fulfills all essential criteria for high throughput screening.