NIR-Triggered Release of Caged Nitric Oxide using Upconverting Nanostructured Materials

Authors

  • John V. Garcia,

    1. Department of Chemistry and Laboratory of Advanced Materials, Fudan University, Shanghai 200433, PR China
    2. Department of Chemistry and Biochemistry, University of California, Santa Barbara, Santa Barbara, CA, 93106 USA
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  • Jianping Yang,

    1. Department of Chemistry and Laboratory of Advanced Materials, Fudan University, Shanghai 200433, PR China
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  • Dengke Shen,

    1. Department of Chemistry and Laboratory of Advanced Materials, Fudan University, Shanghai 200433, PR China
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  • Chi Yao,

    1. Department of Chemistry and Laboratory of Advanced Materials, Fudan University, Shanghai 200433, PR China
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  • Xiaoming Li,

    1. Department of Chemistry and Laboratory of Advanced Materials, Fudan University, Shanghai 200433, PR China
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  • Rui Wang,

    1. Department of Chemistry and Laboratory of Advanced Materials, Fudan University, Shanghai 200433, PR China
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  • Galen D. Stucky,

    Corresponding author
    1. Department of Chemistry and Biochemistry, University of California, Santa Barbara, Santa Barbara, CA, 93106 USA
    • Department of Chemistry and Biochemistry, University of California, Santa Barbara, Santa Barbara, CA, 93106 USA
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  • Dongyuan Zhao,

    Corresponding author
    1. Department of Chemistry and Laboratory of Advanced Materials, Fudan University, Shanghai 200433, PR China
    • Department of Chemistry and Laboratory of Advanced Materials, Fudan University, Shanghai 200433, PR China.
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  • Peter C. Ford,

    Corresponding author
    1. Department of Chemistry and Biochemistry, University of California, Santa Barbara, Santa Barbara, CA, 93106 USA
    • Department of Chemistry and Biochemistry, University of California, Santa Barbara, Santa Barbara, CA, 93106 USA
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  • Fan Zhang

    Corresponding author
    1. Department of Chemistry and Laboratory of Advanced Materials, Fudan University, Shanghai 200433, PR China
    • Department of Chemistry and Laboratory of Advanced Materials, Fudan University, Shanghai 200433, PR China.
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Abstract

original image

Lanthanide-doped upconversion nanoparticles (UCNPs) mediate nitric oxide uncaging from Roussin's black salt anion Fe4S3(NO)7 using NIR light from a simple diode laser operating continuously at 980 nm. This result offers a new paradigm for applications of multi-photon absorption in the therapeutic delivery of NO.

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