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Hyperbranched Conjugated Polyelectrolyte for Dual-modality Fluorescence and Magnetic Resonance Cancer Imaging

Authors

  • Dan Ding,

    1. Department of Chemical and Biomolecular Engineering, National University of Singapore, 117576, Singapore
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  • Guan Wang,

    1. Department of Chemical and Biomolecular Engineering, National University of Singapore, 117576, Singapore
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  • Jianzhao Liu,

    1. Department of Chemistry, The Hong Kong University of Science & Technology, Clear Water Bay, Kowloon, Hong Kong, China
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  • Kai Li,

    1. Department of Chemical and Biomolecular Engineering, National University of Singapore, 117576, Singapore
    2. Institute of Materials Research Engineering, 3 Research Link, 117602, Singapore
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  • Kan-Yi Pu,

    1. Department of Chemical and Biomolecular Engineering, National University of Singapore, 117576, Singapore
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  • Yong Hu,

    1. National Laboratory of Solid-State Microstructure, Department of Material Science and Engineering, Nanjing University, Nanjing 210093, China
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  • Jason C. Y. Ng,

    1. Department of Chemistry, The Hong Kong University of Science & Technology, Clear Water Bay, Kowloon, Hong Kong, China
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  • Ben Zhong Tang,

    1. Department of Chemistry, The Hong Kong University of Science & Technology, Clear Water Bay, Kowloon, Hong Kong, China
    2. Institute of Materials Research Engineering, 3 Research Link, 117602, Singapore
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  • Bin Liu

    Corresponding author
    1. Department of Chemical and Biomolecular Engineering, National University of Singapore, 117576, Singapore
    2. Institute of Materials Research Engineering, 3 Research Link, 117602, Singapore
    • Department of Chemical and Biomolecular Engineering, National University of Singapore, 117576, Singapore.
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Abstract

Herein is reported the synthesis of gadolinium ion (Gd(III))-chelated hyperbranched conjugated polyelectrolyte (HCPE-Gd) and its application in fluorescence and magnetic resonance (MR) dual imaging in live animals. The synthesized HCPE-Gd forms nanospheres with an average diameter of ∼42 nm measured by laser light scattering and a quantum yield of 10% in aqueous solution. The absorption spectrum of HCPE-Gd has two maxima at 318 and 417 nm, and its photoluminescence maximum centers at 591 nm. Confocal laser scanning microscopy studies indicate that the HCPE-Gd is internalized in MCF-7 cancer cell cytoplasm with good photostability and low cytotoxicity. Further fluorescence and MR imaging studies on hepatoma H22 tumor-bearing mouse model reveal that HCPE-Gd can serve as an efficient optical/MR dual-modal imaging nanoprobe for in vivo cancer diagnosis.

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