Non-ionic Dendronized Multiamphiphilic Polymers as Nanocarriers for Biomedical Applications

Authors

  • Shilpi Gupta,

    1. Institut für Chemie und Biochemie, Freie Universität Berlin, Takustraße 3, 14195 Berlin, Germany
    2. Department of Chemistry, University of Delhi, Delhi-110 007, India
    Search for more papers by this author
  • Boris Schade,

    1. Forschungszentrum für Elektronenmikroskopie, Institut für Chemie und Biochemie, Freie Universität Berlin Fabeckstraße 36a, 14195 Berlin, Germany
    Search for more papers by this author
  • Sumit Kumar,

    1. Institut für Chemie und Biochemie, Freie Universität Berlin, Takustraße 3, 14195 Berlin, Germany
    2. Department of Chemistry, Deenbandhu Chhotu Ram University of Science & Technology, Murthal (Sonipat), Haryana-131039, India
    Search for more papers by this author
  • Christoph Böttcher,

    1. Forschungszentrum für Elektronenmikroskopie, Institut für Chemie und Biochemie, Freie Universität Berlin Fabeckstraße 36a, 14195 Berlin, Germany
    Search for more papers by this author
  • Sunil K. Sharma,

    Corresponding author
    1. Department of Chemistry, University of Delhi, Delhi-110 007, India
    • Sunil K. Sharma, Department of Chemistry, University of Delhi, Delhi-110 007, India.

      Rainer Haag, Institut für Chemie und Biochemie, Freie Universität Berlin, Takustraße 3, 14195 Berlin, Germany

    Search for more papers by this author
  • Rainer Haag

    Corresponding author
    1. Institut für Chemie und Biochemie, Freie Universität Berlin, Takustraße 3, 14195 Berlin, Germany
    • Sunil K. Sharma, Department of Chemistry, University of Delhi, Delhi-110 007, India.

      Rainer Haag, Institut für Chemie und Biochemie, Freie Universität Berlin, Takustraße 3, 14195 Berlin, Germany

    Search for more papers by this author

  • The copyright line for this article was changed on 10 Mar 2016 after original online publication.

Abstract

A new class of non-ionic dendronized multiamphiphilic polymers is prepared from a biodegradable (AB)n-type diblock polymer synthesized from 2-azido-1,3-propanediol (azido glycerol) and polyethylene glycol (PEG)-600 diethylester using Novozym-435 (Candida antarctica lipase) as a biocatalyst, following a well-established biocatalytic route. These polymers are functionalized with dendritic polyglycerols (G1 and G2) and octadecyl chains in different functionalization levels via click chemistry to generate dendronized multiamphiphilic polymers. Surface tension measurements and dynamic light scattering studies reveal that all of the multiamphiphilic polymers spontaneously self-assemble in aqueous solution. Cryogenic transmission electron microscopy further proves the formation of multiamphiphiles towards monodisperse spherical micelles of about 7–9 nm in diameter. The evidence from UV–vis and fluorescence spectroscopy suggests the effective solubilization of hydrophobic guests like pyrene and 1-anilinonaphthalene-8-sulfonic acid within the hydrophobic core of the micelles. These results demonstrate the potential of these dendronized multiamphiphilic polymers for the development of prospective drug delivery systems for the solubilization of poorly water soluble drugs.

Ancillary