We would like to dedicate this paper to Florian Mumm, who unfortunately passed away just before the paper was submitted for publication. Florian played an essantial role in the research described here and he is greatly missed.
A Transparent Nanowire-Based Cell Impalement Device Suitable for Detailed Cell–Nanowire Interaction Studies†
Article first published online: 4 OCT 2012
Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Volume 9, Issue 2, pages 263–272, January 28, 2013
How to Cite
Mumm, F., Beckwith, K. M., Bonde, S., Martinez, K. L. and Sikorski, P. (2013), A Transparent Nanowire-Based Cell Impalement Device Suitable for Detailed Cell–Nanowire Interaction Studies. Small, 9: 263–272. doi: 10.1002/smll.201201314
- Issue published online: 21 JAN 2013
- Article first published online: 4 OCT 2012
- Manuscript Revised: 28 AUG 2012
- Manuscript Received: 13 JUN 2012
- copper oxide nanowires;
- cell membrane interactions
A method to fabricate inexpensive and transparent nanowire impalement devices is invented based on CuO nanowire arrays grown by thermal oxidation. By employing a novel process the nanowires are transferred to a transparent, cell-compatible epoxy membrane. Cargo delivery and detailed cell-nanowire interaction studies are performed, revealing that the cell plasma membrane tightly wraps the nanowires, while cell membrane penetration is not observed. The presented device offers an efficient investigation platform for further optimization, leading towards a simple and versatile impalement delivery system.