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Physicochemical Characteristics of Nanoparticles Affect Circulation, Biodistribution, Cellular Internalization, and Trafficking

Authors

  • Xiaopin Duan,

    1. Center of Pharmaceutics, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China, Tel: +86-21-2023-1979, Fax: +86-21-2023-1979
    2. School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, China
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  • Yaping Li

    Corresponding author
    1. Center of Pharmaceutics, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China, Tel: +86-21-2023-1979, Fax: +86-21-2023-1979
    • Center of Pharmaceutics, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China, Tel: +86-21-2023-1979, Fax: +86-21-2023-1979.
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Abstract

Nanoparticles have many potential applications in tumor therapy. Systemically administered nanoparticles should remain in circulation for a long time to increase their accumulation in targeted tissues before being cleared by the reticuloendothelial system, and be effectively internalized by the targeted cells, which can be influenced significantly by the physicochemical characteristics of nanoparticles, such as particle size, surface properties, and particle shape. This review highlights the impact of the main affects of physicochemical properties on nanoparticle transport behavior in blood, their uptake and clearance by macrophages and their consequent biodistribution, as well as their interaction with targeted cells.

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