Communication

Spontaneous Formation of Heterogeneous Patches on Polymer–Lipid Core–Shell Particle Surfaces during Self-Assembly

  1. Carolina Salvador-Morales1,†,
  2. Pedro M. Valencia2,
  3. Weiwei Gao1,
  4. Rohit Karnik3,
  5. Omid C. Farokhzad1,*

Article first published online: 26 OCT 2012

DOI: 10.1002/smll.201201499

Issue

Small

Small

Volume 9, Issue 4, pages 511–517, February 25, 2013

Additional Information

How to Cite

Salvador-Morales, C., Valencia, P. M., Gao, W., Karnik, R. and Farokhzad, O. C. (2013), Spontaneous Formation of Heterogeneous Patches on Polymer–Lipid Core–Shell Particle Surfaces during Self-Assembly. Small, 9: 511–517. doi: 10.1002/smll.201201499

Author Information

  1. 1

    Laboratory of Nanomedicine and Biomaterials, Department of Anesthesiology, Brigham and Women's Hospital-Harvard Medical School, Boston, MA 02115, USA

  2. 2

    Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA

  3. 3

    Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA

  1. †

    Bioengineering Department, George Mason University, 4400 University Drive, MS 1G5, Fairfax, VA 22030, USA

*Laboratory of Nanomedicine and Biomaterials, Department of Anesthesiology, Brigham and Women's Hospital-Harvard Medical School, Boston, MA 02115, USA.

Publication History

  1. Issue published online: 15 FEB 2013
  2. Article first published online: 26 OCT 2012
  3. Manuscript Revised: 29 AUG 2012
  4. Manuscript Received: 30 JUN 2012

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Keywords:

  • patchy particles;
  • self-assembly;
  • multifunctional particles;
  • polymer–lipid;
  • core–shell
Thumbnail image of graphical abstract

Spontaneous formation of heterogeneous patches on the surface of lipid-based nanoparticles (NPs) and microparticles (MPs) due to the segregation of two different functional groups. Patch formation is observed when tracing the functional groups with quantum dots, gold nanoparticles, and fluorescent dyes. This discovery could have important implications for the future design of self-assembled NPs and MPs for different biomedical applications.

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