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Spontaneous Formation of Heterogeneous Patches on Polymer–Lipid Core–Shell Particle Surfaces during Self-Assembly

Authors

  • Carolina Salvador-Morales,

    1. Laboratory of Nanomedicine and Biomaterials, Department of Anesthesiology, Brigham and Women's Hospital-Harvard Medical School, Boston, MA 02115, USA
    Current affiliation:
    1. Bioengineering Department, George Mason University, 4400 University Drive, MS 1G5, Fairfax, VA 22030, USA
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  • Pedro M. Valencia,

    1. Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
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  • Weiwei Gao,

    1. Laboratory of Nanomedicine and Biomaterials, Department of Anesthesiology, Brigham and Women's Hospital-Harvard Medical School, Boston, MA 02115, USA
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  • Rohit Karnik,

    1. Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
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  • Omid C. Farokhzad

    Corresponding author
    1. Laboratory of Nanomedicine and Biomaterials, Department of Anesthesiology, Brigham and Women's Hospital-Harvard Medical School, Boston, MA 02115, USA
    • Laboratory of Nanomedicine and Biomaterials, Department of Anesthesiology, Brigham and Women's Hospital-Harvard Medical School, Boston, MA 02115, USA.
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Abstract

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Spontaneous formation of heterogeneous patches on the surface of lipid-based nanoparticles (NPs) and microparticles (MPs) due to the segregation of two different functional groups. Patch formation is observed when tracing the functional groups with quantum dots, gold nanoparticles, and fluorescent dyes. This discovery could have important implications for the future design of self-assembled NPs and MPs for different biomedical applications.

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