Artificial Cytoskeletal Structures Within Enzymatically Active Bio-inorganic Protocells

Authors

  • Ravinash Krishna Kumar,

    1. Centre for Organized Matter Chemistry, School of Chemistry, University of Bristol, Bristol, BS8 1TS, UK
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  • Mei Li,

    1. Centre for Organized Matter Chemistry, School of Chemistry, University of Bristol, Bristol, BS8 1TS, UK
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  • Sam N. Olof,

    1. Centre for Organized Matter Chemistry, School of Chemistry, University of Bristol, Bristol, BS8 1TS, UK
    2. Bristol Centre for Functional Nanomaterials, Centre for NSQI, University of Bristol, BS8 1FD, UK
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  • Avinash J. Patil,

    1. Centre for Organized Matter Chemistry, School of Chemistry, University of Bristol, Bristol, BS8 1TS, UK
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  • Stephen Mann

    Corresponding author
    1. Centre for Organized Matter Chemistry, School of Chemistry, University of Bristol, Bristol, BS8 1TS, UK
    • Centre for Organized Matter Chemistry, School of Chemistry, University of Bristol, Bristol, BS8 1TS, UK.
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Abstract

original image

The fabrication of enzymatically active, semi-permeable bio-inorganic protocells capable of self-assembling a cytoskeletal-like interior and undergoing small-molecule dephosphorylation reactions is described. Reversible disassembly of an amino acid-derived supramolecular hydrogel within the internalized reaction space is used to tune the enzymatic activity of the nanoparticle-bounded inorganic compartments.

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