Silver Nanoparticles Decrease Body Weight and Locomotor Activity in Adult Male Rats

Authors

  • Yongbin Zhang,

    Corresponding author
    1. Nanotechnology Core Facility, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079, USA
    Current affiliation:
    1. These two authors contributed equally to this work.
    • Nanotechnology Core Facility, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079, USA
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  • Sherry A. Ferguson,

    Corresponding author
    1. Division of Neurotoxicology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079, USA
    Current affiliation:
    1. These two authors contributed equally to this work.
    • Division of Neurotoxicology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079, USA.
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  • Fumiya Watanabe,

    1. Nanotechnology Center, University of Arkansas at Little Rock, Little Rock, AR 72204, USA
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  • Yvonne Jones,

    1. Nanotechnology Core Facility, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079, USA
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  • Yang Xu,

    1. Nanotechnology Center, University of Arkansas at Little Rock, Little Rock, AR 72204, USA
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  • Alexandru S. Biris,

    1. Nanotechnology Center, University of Arkansas at Little Rock, Little Rock, AR 72204, USA
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  • Saber Hussain,

    1. Applied Biotechnology Branch, Human Effectiveness Directorate, Air Force Research Laboratory, Wright-Patterson Air Force Base, OH 45433, USA
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  • Syed F. Ali

    1. Division of Neurotoxicology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079, USA
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Abstract

original image

Silver nanoparticles (Ag-NPs) are widely used in FDA regulated products. The physical-chemical properties of Ag-NPs are characterized using various instruments. The dose-dependent activity and body weight alterations are evaluated after rats were exposed to Ag nanoparticles, suggesting a major human health risk, given the wide application of silver nanomaterials.

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