Colorimetric Protein Sensing Using Catalytically Amplified Sensor Arrays



original image

Catalytically active iron oxide nanoparticles are used as recognition elements and signal amplifiers for the array-based colorimetric sensing of proteins. Interactions between cationic monolayers on the Fe3O4 NPs and analyte proteins differentially modulates the peroxidase-like activity of Fe3O4 NPs, affording catalytically amplified colorimetric signal patterns that enable the detection and identification of proteins at 50 nM.