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Keywords:

  • protein sensing;
  • colorimetry;
  • sensor arrays;
  • iron oxide nanoparticles
Thumbnail image of graphical abstract

Catalytically active iron oxide nanoparticles are used as recognition elements and signal amplifiers for the array-based colorimetric sensing of proteins. Interactions between cationic monolayers on the Fe3O4 NPs and analyte proteins differentially modulates the peroxidase-like activity of Fe3O4 NPs, affording catalytically amplified colorimetric signal patterns that enable the detection and identification of proteins at 50 nM.