Continuous Coaxial Electrohydrodynamic Atomization System for Water-Stable Wrapping of Magnetic Nanoparticles

Authors

  • Sang-Yoon Kim,

    1. Department of Mechanical Engineering, Yonsei University, Seoul 120-749, Republic of Korea
    Current affiliation:
    1. These authors contributed equally to this work.
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  • Jaemoon Yang,

    1. Department of Radiology, Yonsei University, Seoul 120-752, Republic of Korea
    2. Severance Integrative Research Institute for Cerebral & Cardiovascular Diseases, Yonsei University Health System, Seoul 120-752, Republic of Korea
    3. YUHS-KRIBB Medical Convergence Research Institute, Seoul 120-752, Republic of Korea
    Current affiliation:
    1. These authors contributed equally to this work.
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  • Bongjune Kim,

    1. Department of Chemical and Biomolecular Engineering, Yonsei University, Seoul 120-749, Republic of Korea
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  • Jungmin Park,

    1. Department of Radiology, Yonsei University, Seoul 120-752, Republic of Korea
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  • Jin-Suck Suh,

    1. YUHS-KRIBB Medical Convergence Research Institute, Seoul 120-752, Republic of Korea
    2. Severance Biomedical Science Institute (SBSI), Seoul 120-752, Republic of Korea
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  • Yong-Min Huh,

    1. Department of Radiology, Yonsei University, Seoul 120-752, Republic of Korea
    2. YUHS-KRIBB Medical Convergence Research Institute, Seoul 120-752, Republic of Korea
    3. Severance Biomedical Science Institute (SBSI), Seoul 120-752, Republic of Korea
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  • Seungjoo Haam,

    1. YUHS-KRIBB Medical Convergence Research Institute, Seoul 120-752, Republic of Korea
    2. Department of Chemical and Biomolecular Engineering, Yonsei University, Seoul 120-749, Republic of Korea
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  • Jungho Hwang

    Corresponding author
    1. Department of Mechanical Engineering, Yonsei University, Seoul 120-749, Republic of Korea
    • Department of Mechanical Engineering, Yonsei University, Seoul 120-749, Republic of Korea.

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Abstract

An electrohydrodynamic atomization (EHDA) system that generates an electrospray can achieve particle formation and encapsulation by accumulating an electric charge on liquid flowing out from the nozzle. A novel coaxial EHDA system for continuous fabrication of water-stable magnetic nanoparticles (MNPs) is established, based on a cone-jet mode of electrospraying. Systemic variables, such as flow rates from dual nozzles and inducing voltages, are controlled to enable the preparation of water-soluble MNPs coated by polysorbate 80. The PEGylated MNPs exhibit water stability. The magnetic resonance imaging potential of these MNPs is confirmed by in vivo imaging using a gastric cancer xenograft mouse model. Thus, this advanced coaxial EHDA system demonstrates remarkable capabilities for the continuous encapsulation of MNPs to render them water-stable while preserving their properties as imaging agents.

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