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Nanoporous Gold Channel with Attached DNA Nanolock for Drug Screening

Authors

  • Jiandong Feng,

    1. Institute of Microanalytical Systems, Department of Chemistry, Zhejiang University, Hangzhou 310058, China
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  • Jianmin Wu

    Corresponding author
    1. Institute of Microanalytical Systems, Department of Chemistry, Zhejiang University, Hangzhou 310058, China
    • Institute of Microanalytical Systems, Department of Chemistry, Zhejiang University, Hangzhou 310058, China.
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Abstract

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Soft matter, easily deformed by weak interactions, can act as a sensing element based on stimuli-responsive conformational change. When combined with solid-state nanomaterials, the mechanical actuation is transformed into an optical or electrical signal. DNA molecules can control the pore accessibility of nanoporous gold, acting as a smart nanolock. Application in the screening of anticancer drugs is demonstrated.

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