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Photosensitizer-Incorporated Quadruplex DNA-Gated Nanovechicles for Light-Triggered, Targeted Dual Drug Delivery to Cancer Cells

Authors

  • Cuie Chen,

    1. State Key Laboratory of Rare, Earth Resources Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, PR China
    2. Laboratory of Chemical Biology, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, PR China
    3. Graduate School of the Chinese Academy of Sciences, Beijing 100039, PR China
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  • Li Zhou,

    1. State Key Laboratory of Rare, Earth Resources Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, PR China
    2. Laboratory of Chemical Biology, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, PR China
    3. Graduate School of the Chinese Academy of Sciences, Beijing 100039, PR China
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  • Jie Geng,

    1. State Key Laboratory of Rare, Earth Resources Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, PR China
    2. Laboratory of Chemical Biology, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, PR China
    3. Graduate School of the Chinese Academy of Sciences, Beijing 100039, PR China
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  • Jinsong Ren,

    Corresponding author
    1. State Key Laboratory of Rare, Earth Resources Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, PR China
    2. Laboratory of Chemical Biology, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, PR China
    3. Graduate School of the Chinese Academy of Sciences, Beijing 100039, PR China
    • State Key Laboratory of Rare, Earth Resources Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, PR China.
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  • Xiaogang Qu

    Corresponding author
    1. State Key Laboratory of Rare, Earth Resources Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, PR China
    2. Laboratory of Chemical Biology, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, PR China
    3. Graduate School of the Chinese Academy of Sciences, Beijing 100039, PR China
    • State Key Laboratory of Rare, Earth Resources Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, PR China.
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Abstract

A novel light-operated vehicle for targeted intracellular drug delivery is constructed using photosensitizer-incorporated G-quadruplex DNA-capped mesoporous silica nanoparticles. Upon light irradiation, the photosensitizer generates ROS, causing the DNA capping to be cleaved and allowing cargo to be released. Importantly, this platform makes it possible to develop a drug-carrier system for the synergistic combination of chemotherapy and PDT for cancer treatment with spatial/temporal control. Furthermore, the introducing of targeting ligands further improves tumor targeting efficiency. The excellent biocompatibility, cell-specific intracellular drug delivery, and cellular uptake properties set up the basis for future biomedical application that require in vivo controlled, targeted drug delivery.

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