Photoswitchable Particles for On-Demand Degradation and Triggered Release

Authors

  • Tae-Hong Park,

    1. Department of Chemical Engineering, University of Michigan, Ann Arbor, Michigan 48109, USA
    Current affiliation:
    1. Nuclear Chemistry Research Division, Korea Atomic Energy Research Institute (KAERI), Daejeon, 305-353, Korea
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  • Thomas W. Eyster,

    1. Department of Chemical Engineering, University of Michigan, Ann Arbor, Michigan 48109, USA
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  • Joshua M. Lumley,

    1. Department of Chemical Engineering, University of Michigan, Ann Arbor, Michigan 48109, USA
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  • Sangyeul Hwang,

    1. Department of Chemical Engineering, University of Michigan, Ann Arbor, Michigan 48109, USA
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  • Kyung Jin Lee,

    1. Department of Chemical Engineering, University of Michigan, Ann Arbor, Michigan 48109, USA
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  • Asish Misra,

    1. Biomedical Engineering, University of Michigan, Ann Arbor, Michigan 48109, USA
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  • Sahar Rahmani,

    1. Biomedical Engineering, University of Michigan, Ann Arbor, Michigan 48109, USA
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  • Joerg Lahann

    Corresponding author
    1. Department of Chemical Engineering, University of Michigan, Ann Arbor, Michigan 48109, USA
    2. Department of Materials Science and Engineering, University of Michigan, Ann Arbor, 48109, USA
    3. Department of Macromolecular Science and Engineering, University of Michigan, Ann Arbor, 48109, USA
    4. Department of Biomedical Engineering, University of Michigan, Ann Arbor, 48109, USA
    • Department of Chemical Engineering, University of Michigan, Ann Arbor, Michigan 48109, USA.
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Abstract

original image

On-demand degradable polymer particles are fabricated via electrospraying of a solution of acetal-protected dextran that further includes 2-(4-methoxystyryl)-4,6-bis(trichloromethyl)-1,3,5-triazine as a photoacid generator. The illumination of UV light gives rise to photoacid and activates the catalytic deprotection of hydroxyl groups of dextran, leading to controlled dissolution of the microparticles in water.

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