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Protein-Protected Au Clusters as a New Class of Nanoscale Biosensor for Label-Free Fluorescence Detection of Proteases

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Destruction for detection: Protein-protected Au clusters are exploited as nanoscale sensors for label-free fluorescence detection of proteases with high sensitivity. The detection mechanism is based on degradation of the protein shell by a protease, allowing the O2 from ambient air to penetrate through and quench the fluorescence from the Au cluster.

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