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Evaluation of Cell Function Upon Nanovector Internalization

Authors

  • Jonathan O. Martinez,

    1. Department of Nanomedicine, The Methodist Hospital Research Institute, 6670 Bertner Ave. MS R7-414 Houston, TX 77030, USA
    2. Graduate School of Biomedical Sciences, University of Texas Health Science Center at Houston, Houston, TX, USA
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  • Alessandro Parodi,

    1. Department of Nanomedicine, The Methodist Hospital Research Institute, 6670 Bertner Ave. MS R7-414 Houston, TX 77030, USA
    2. Department of Experimental Oncology and Molecular Medicine, Fondazione IRCCS Istituto Nazionale Tumori, Milan 20133, Italy
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  • Xuewu Liu,

    1. Department of Nanomedicine, The Methodist Hospital Research Institute, 6670 Bertner Ave. MS R7-414 Houston, TX 77030, USA
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  • Mikhail G. Kolonin,

    1. The Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX, USA
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  • Mauro Ferrari,

    1. Department of Nanomedicine, The Methodist Hospital Research Institute, 6670 Bertner Ave. MS R7-414 Houston, TX 77030, USA
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  • Ennio Tasciotti

    Corresponding author
    1. Department of Nanomedicine, The Methodist Hospital Research Institute, 6670 Bertner Ave. MS R7-414 Houston, TX 77030, USA
    • Department of Nanomedicine, The Methodist Hospital Research Institute, 6670 Bertner Ave. MS R7-414 Houston, TX 77030, USA.
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Abstract

original image

In vitro toxicity assays based on the evaluation and retention of advanced and specific cellular functions are proposed to investigate mesoporous silicon nanovectors. This approach provides greater insight compared to simple cellular viability and toxicity assays. Electron microscopy images demonstrate internalized nanovectors altering the curvature of the nuclear envelope with minimal effect on viability or biological function.

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