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Replication of Bone Marrow Differentiation Niche: Comparative Evaluation of Different Three-Dimensional Matrices

Authors

  • Meghan J. Cuddihy,

    1. Department of Chemical Engineering, University of Michigan, 3074 H. H. Dow Building, 2300 Hayward Street, Ann Arbor, MI 48109, USA
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  • Yichun Wang,

    1. Department of Biomedical Engineering, 3074 H. H. Dow Building, 2300 Hayward Street, Ann Arbor, MI 48109, USA
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  • Charles Machi,

    1. Department of Chemical Engineering, University of Michigan, 3074 H. H. Dow Building, 2300 Hayward Street, Ann Arbor, MI 48109, USA
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  • Joong Hwan Bahng,

    1. Department of Biomedical Engineering, 3074 H. H. Dow Building, 2300 Hayward Street, Ann Arbor, MI 48109, USA
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  • Nicholas A. Kotov

    Corresponding author
    1. Department of Chemical Engineering, University of Michigan, 3074 H. H. Dow Building, 2300 Hayward Street, Ann Arbor, MI 48109, USA
    2. Department of Biomedical Engineering, 3074 H. H. Dow Building, 2300 Hayward Street, Ann Arbor, MI 48109, USA
    3. Department of Material Sciences and Engineering, Biointerface Institute, University of Michigan, 3074 H. H. Dow Building, 2300 Hayward Street, Ann Arbor, MI 48109, USA
    • Department of Chemical Engineering, University of Michigan, 3074 H. H. Dow Building, 2300 Hayward Street, Ann Arbor, MI 48109, USA.
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Abstract

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The comparative evaluation of different 3D matrices—Matrigel, Puramatrix, and inverted colloidal crystal (ICC) scaffolds—provides a perspective for studying the pathology and potential cures for many blood and bone marrow diseases, and further proves the significance of 3D cultures with direct cell–cell contacts for in vitro mimicry of the human stem cell niche.

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