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Biomimetic Methodology to Produce Polymeric Multilayered Particles for Biotechnological and Biomedical Applications

Authors

  • Ana Catarina Lima,

    1. 3B's Research Group–Biomaterials, Biodegradables and Biomimetics, University of Minho, AvePark, Zona Industrial da Gandra, S. Claudio do Barco, 4806-909 Caldas das Taipas, Giomarães, Portugal
    2. ICVC/3B's–PT Government Associate Laboratory, Braga/Guimarães, Portugal
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  • Catarina A. Custódio,

    1. 3B's Research Group–Biomaterials, Biodegradables and Biomimetics, University of Minho, AvePark, Zona Industrial da Gandra, S. Claudio do Barco, 4806-909 Caldas das Taipas, Giomarães, Portugal
    2. ICVC/3B's–PT Government Associate Laboratory, Braga/Guimarães, Portugal
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  • Carmen Alvarez-Lorenzo,

    1. Departamento de Farmacia y Tecnología Farmacéutica, Facultad de Farmacia, Universidad de Santiago de Compostela, 15782 Santiago de Compostela, Spain
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  • João F. Mano

    Corresponding author
    1. 3B's Research Group–Biomaterials, Biodegradables and Biomimetics, University of Minho, AvePark, Zona Industrial da Gandra, S. Claudio do Barco, 4806-909 Caldas das Taipas, Giomarães, Portugal
    2. ICVC/3B's–PT Government Associate Laboratory, Braga/Guimarães, Portugal
    • 3B's Research Group–Biomaterials, Biodegradables and Biomimetics, University of Minho, AvePark, Zona Industrial da Gandra, S. Claudio do Barco, 4806-909 Caldas das Taipas, Giomarães, Portugal.
    Search for more papers by this author

Abstract

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The production of multi-compartmented particles for biomedical and biotechnological applications is challenging and the existing methods usually involve wet and aggressive conditions that compromise the encapsulation efficiency of bioactive agents and the viability of cells. Biomimetic superhydrophobic surfaces allow construction of concentric multilayered polymeric systems, adding sequential layers where molecules or cells may be separately confined in compartments with high efficiency.

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