Surpassing the physical barriers of the cytoplasmic and nuclear membranes to deliver biomolecules directly into cell nuclei offers opportunities to investigate dynamic processes in living cells. The potential of atomic force microscopy coupled to microfluidics (FluidFM) for volume-controlled intranuclear delivery is demonstrated, whereby minimally invasive microchanneled probes are remotely driven with high spatiotemporal resolution.
If you can't find a tool you're looking for, please click the link at the top of the page to "Go to old article view". Alternatively, view our Knowledge Base articles for additional help. Your feedback is important to us, so please let us know if you have comments or ideas for improvement.