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The Role of Surface Chemistry on the Toxicity of Ag Nanoparticles

Authors

  • Yujie Xiong,

    Corresponding author
    1. Nano Research Facility, School of Engineering and Applied Science, Washington University, St. Louis, Missouri 63130, USA
    2. Hefei National Laboratory for Physical Sciences at the Microscale, University of Science and Technology of China, Hefei, Anhui 230026, PR China
    • Nano Research Facility, School of Engineering and Applied Science, Washington University, St. Louis, Missouri 63130, USA.
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  • Mark Brunson,

    1. Department of Mechanical Engineering, San Francisco State University, San Francisco, California 94110, USA
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  • Juyoung Huh,

    1. Department of Genetics and Center for Genome, Sciences and Systems Biology, Washington University School of Medicine, St. Louis, Missouri 63108, USA
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  • Aaron Huang,

    1. Department of Energy, Environmental, and Chemical Engineering, Washington University, St. Louis, Missouri 63130, USA
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  • Adam Coster,

    1. Department of Genetics and Center for Genome, Sciences and Systems Biology, Washington University School of Medicine, St. Louis, Missouri 63108, USA
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  • Kristy Wendt,

    1. Nano Research Facility, School of Engineering and Applied Science, Washington University, St. Louis, Missouri 63130, USA
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  • Justin Fay,

    1. Department of Genetics and Center for Genome, Sciences and Systems Biology, Washington University School of Medicine, St. Louis, Missouri 63108, USA
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  • Dong Qin

    Corresponding author
    1. Nano Research Facility, School of Engineering and Applied Science, Washington University, St. Louis, Missouri 63130, USA
    2. Department of Energy, Environmental, and Chemical Engineering, Washington University, St. Louis, Missouri 63130, USA
    3. School of Materials Science and Engineering, Georgia Institute of Technology, Atlanta, Georgia 30332-0245, USA
    • Nano Research Facility, School of Engineering and Applied Science, Washington University, St. Louis, Missouri 63130, USA.
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Abstract

The role of surface chemistry on the toxicity of Ag nanoparticles is investigated using Saccharomyces cerevisiae yeast as a platform for evaluation. Combining the shape-controlled synthesis of Ag nanoparticles with a comprehensive characterization of their physicochemical properties, an understanding is formed of the correlation between the physicochemical parameters of nanoparticles and the inhibition growth of yeast cells upon the introduction of nanoparticles into the cell culture system. Capping agents, surface facets, and sample stability—the three experimental parameters that are inherent from the wet-chemical synthesis of Ag nanoparticles—have a strong impact on toxicity evaluation. Hence, it is important to characterize surface properties of Ag nanoparticles in the nature of biological media and to understand the role that surface chemistry may interplay to correlate the physicochemical properties of nanoparticles with their biological response upon exposure. This work demonstrates the great importance of surface chemistry in designing experiments for reliable toxicity evaluation and in mitigating the toxicity of Ag nanoparticles for their safe use in future commercialization.

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