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Single-Vesicle Patterning of Uniform, Giant Polymersomes into Microarrays

Authors

  • Neha P. Kamat,

    1. Department of Bioengineering, University of Pennsylvania, 210 South 33rd Street, Philadelphia, PA 19104, USA
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  • Steven J. Henry,

    1. Department of Bioengineering, University of Pennsylvania, 210 South 33rd Street, Philadelphia, PA 19104, USA
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  • Daeyeon Lee,

    1. Department of Chemical and Biomolecular Engineering, University of Pennsylvania, 220 South 33rd Street, Philadelphia, PA 19104, USA
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  • Daniel A. Hammer

    Corresponding author
    1. Department of Bioengineering, University of Pennsylvania, 210 South 33rd Street, Philadelphia, PA 19104, USA
    2. Department of Chemical and Biomolecular Engineering, University of Pennsylvania, 220 South 33rd Street, Philadelphia, PA 19104, USA
    • Department of Bioengineering, University of Pennsylvania, 210 South 33rd Street, Philadelphia, PA 19104, USA.

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Abstract

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Giant, cell-sized polymersomes are functionalized and patterned at the single vesicle level. Microfluidic methods are employed to generate uniform diameter vesicles with high loading efficiencies and microcontact printing is used to generate patterns of adhesive ligand. A simple sensory capability is demonstrated with the immobilized array of vesicles.

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