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Tandem Assays of Protein and Glucose with Functionalized Core/Shell Particles Based on Magnetic Separation and Surface-Enhanced Raman Scattering

Authors

  • Xianming Kong,

    1. Key Laboratory of Mesoscopic Chemistry, (Ministry of Education), State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, China
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  • Qian Yu,

    1. Key Laboratory of Mesoscopic Chemistry, (Ministry of Education), State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, China
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  • Zhongpeng Lv,

    1. Key Laboratory of Mesoscopic Chemistry, (Ministry of Education), State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, China
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  • Xuezhong Du

    Corresponding author
    1. Key Laboratory of Mesoscopic Chemistry, (Ministry of Education), State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, China
    • Key Laboratory of Mesoscopic Chemistry, (Ministry of Education), State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, China.
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Abstract

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Tandem assays of protein and glucose in combination with mannose-functionalized Fe3O4@SiO2 and Ag@SiO2 tag particles have promising potential in effective magnetic separation and highly sensitive and selective SERS assays of biomaterials. It is for the first time that tandem assay of glucose is developed using SERS based on the Con A-sandwiched microstructures between the functionalized magnetic and tag particles.

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