Biomimetic Mineralization: The Role of Nanoscale Architecture in Supramolecular Templating of Biomimetic Hydroxyapatite Mineralization (Small 14/2012)

Authors

  • Christina J. Newcomb,

    1. Department of Materials Science and Engineering Northwestern University, Evanston, IL, USA
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  • Ronit Bitton,

    1. The Institute for BioNanotechnology in Medicine, Northwestern University, Chicago, IL, USA
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  • Yuri S. Velichko,

    1. Department of Materials Science and Engineering Northwestern University, Evanston, IL, USA
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  • Malcolm L. Snead,

    1. The Center for Craniofacial Molecular Biology, CSA 142, Health Sciences Campus, Herman Ostrow School of Dentistry, University of Southern California, Los Angeles, CA, USA
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  • Samuel I. Stupp

    Corresponding author
    1. Department of Materials Science and Engineering Northwestern University, Evanston, IL, USA
    2. The Institute for BioNanotechnology in Medicine, Northwestern University, Chicago, IL, USA
    3. Department of Chemistry, Northwestern University, Evanston, IL, USA
    4. Department of Medicine, Northwestern University, Chicago, IL, USA
    • Department of Materials Science and Engineering Northwestern University, Evanston, IL, USA.
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Abstract

original image

When 3D peptide amphiphile assemblies with flat and cylindrical morphologies are used as templates for mineralization, the nanoscale architecture is found to play a significant role in orienting hydroxyapatite in a bone-like fashion. Cylindrical nanostructures facilitate mineral orientation parallel to the long axis of the 1D assembly while flatter, ribbonlike architectures nucleate randomly oriented mineral. Macroscopically aligned constructs of the cylindrical nanostructures further demonstrate the ability to orient hydroxyapatite across length scales. This work by S. I. Stupp and co-workers emphasizes the importance of template morphology.

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