Biosensors: CdSe Quantum Dots Enhance Electrical and Electrochemical Signals of Nanogap Devices for Bioanalysis (Small 21/2012)

Authors

  • Yang Yu,

    1. Research Center for Biomimetic Functional, Materials and Sensing Devices, Institute of Intelligent Machines, Chinese Academy of Sciences, Hefei 230031, PR China
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  • Xing Chen,

    1. Research Center for Biomimetic Functional, Materials and Sensing Devices, Institute of Intelligent Machines, Chinese Academy of Sciences, Hefei 230031, PR China
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  • Yan Wei,

    1. Department of Chemistry, Wannan Medical College, Wuhu 241002, PR China
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  • Jin-Huai Liu,

    1. Research Center for Biomimetic Functional, Materials and Sensing Devices, Institute of Intelligent Machines, Chinese Academy of Sciences, Hefei 230031, PR China
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  • Shu-Hong Yu,

    1. Department of Chemistry, University of Science and Technology of China, Hefei 230026, PR China
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  • Xing-Jiu Huang

    Corresponding author
    1. Research Center for Biomimetic Functional, Materials and Sensing Devices, Institute of Intelligent Machines, Chinese Academy of Sciences, Hefei 230031, PR China
    • Research Center for Biomimetic Functional, Materials and Sensing Devices, Institute of Intelligent Machines, Chinese Academy of Sciences, Hefei 230031, PR China.
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Abstract

original image

Electrical and electrochemical signals are enhanced by CdSe quantum dots in a nanogap device for biotin–streptavidin sensing events, as demonstrated by X.-J. Huang and co-workers on page 3274. By employing CdSe quantum dots, the ejection of the conduction-band electrons to the streptavidin, with a concomitant transfer of electrons from the chain of biotin–streptavidin to the gold nanoparticle electrode, yields an enhanced current signal. This work could provide a massive multiplexing, high-throughput, and high-sensitivity technique for biosensing through the use of large microelectrode arrays.

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