Neuron Adhesion: Control of Cell Adhesion and Neurite Outgrowth by Patterned Gold Nanoparticles with Tunable Attractive or Repulsive Surface Properties (Small 21/2012)

Authors

  • Sandra Gilles,

    1. Peter Grünberg Institute (PGI-8), Forschungszentrum Jülich GmbH, 52428 Jülich, Germany
    2. JARA—Fundamentals of Future Information Technology, Germany
    3. Institute of Inorganic Chemistry, RWTH Aachen University, 52074 Aachen, Germany
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  • Silke Winter,

    1. Peter Grünberg Institute (PGI-8), Forschungszentrum Jülich GmbH, 52428 Jülich, Germany
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  • Kristin E. Michael,

    1. Peter Grünberg Institute (PGI-8), Forschungszentrum Jülich GmbH, 52428 Jülich, Germany
    Current affiliation:
    1. Published post-humously, deceased January 2011
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  • Simone H. Meffert,

    1. Peter Grünberg Institute (PGI-8), Forschungszentrum Jülich GmbH, 52428 Jülich, Germany
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  • Pinggui Li,

    1. Peter Grünberg Institute (PGI-8), Forschungszentrum Jülich GmbH, 52428 Jülich, Germany
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  • Kyrylo Greben,

    1. Peter Grünberg Institute (PGI-8), Forschungszentrum Jülich GmbH, 52428 Jülich, Germany
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  • Ulrich Simon,

    1. JARA—Fundamentals of Future Information Technology, Germany
    2. Institute of Inorganic Chemistry, RWTH Aachen University, 52074 Aachen, Germany
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  • Andreas Offenhäusser,

    1. Peter Grünberg Institute (PGI-8), Forschungszentrum Jülich GmbH, 52428 Jülich, Germany
    2. JARA—Fundamentals of Future Information Technology, Germany
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  • Dirk Mayer

    Corresponding author
    1. Peter Grünberg Institute (PGI-8), Forschungszentrum Jülich GmbH, 52428 Jülich, Germany
    2. JARA—Fundamentals of Future Information Technology, Germany
    • Peter Grünberg Institute (PGI-8), Forschungszentrum Jülich GmbH, 52428 Jülich, Germany.
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Abstract

original image

A colorized neurite of a rat cortical neuron is shown growing on a pattern of gold nanoparticles (AuNPs). The background image illustrates a larger area of AuNPs assembled in a pattern predefined by nanoimprint lithography. The AuNPs are equipped with different surface functionalities by D. Mayer and co-workers on page 3357, and used to investigate patterned neuron surface adhesion and neurite outgrowth. The neurites can be guided between or along the pattern using bare AuNPs or particles with positively charged ligands. Surface areas are easily switched between being cellattractive/repulsive by simple thiol chemistry.

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