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Quantum Dots: A Quantum Dot Photoswitch for DNA Detection, Gene Transfection, and Live-Cell Imaging (Small 22/2012)

  1. Yuzhou Wu1,
  2. Klaus Eisele1,
  3. Mikheil Doroshenko2,
  4. Gerardo Algara-Siller3,4,
  5. Ute Kaiser3,
  6. Kaloian Koynov2,
  7. Tanja Weil1,*

Article first published online: 14 NOV 2012

DOI: 10.1002/smll.201290122

Issue

Small

Small

Volume 8, Issue 22, page 3381, November 19, 2012

Additional Information

How to Cite

Wu, Y., Eisele, K., Doroshenko, M., Algara-Siller, G., Kaiser, U., Koynov, K. and Weil, T. (2012), Quantum Dots: A Quantum Dot Photoswitch for DNA Detection, Gene Transfection, and Live-Cell Imaging (Small 22/2012). Small, 8: 3381. doi: 10.1002/smll.201290122

Author Information

  1. 1

    Institute of Organic Chemistry III, Macromolecular Chemistry, Albert-Einstein-Allee 11, 89081 Ulm, Germany

  2. 2

    Max-Planck-Institute for Polymer Research, Ackermannweg 10, 55128 Mainz, Germany

  3. 3

    Electron Microscopy of Materials Science, University of Ulm, 89069 Ulm, Germany

  4. 4

    Technical University Ilmenau, 98693 Ilmenau, Germany

*Institute of Organic Chemistry III, Macromolecular Chemistry, Albert-Einstein-Allee 11, 89081 Ulm, Germany.

Publication History

  1. Issue published online: 14 NOV 2012
  2. Article first published online: 14 NOV 2012

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Keywords:

  • fluorescence correlation spectroscopy;
  • gene delivery;
  • imaging;
  • photoluminescence;
  • quantum dots
Thumbnail image of graphical abstract

The preparation of a protein-derived biopolymer coating for encapsulating quantum dots (QDs) by multivalent interactions is described on page 3465 by T. Weil and co-workers. Coated QDs undergo fast endocytosis, and they are highly stable and noncytotoxic in live cells. The formation of complexes containing QDs and plasmid DNA leads to proportionally decreased photoluminescence of the QDs. Efficient gene transfection is achieved, which is attractive for live-cell bioimaging and mechanistic studies of non-viral gene delivery.

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