Drug Delivery: Synergistic Targeting of Cancer and Associated Angiogenesis Using Triple-Targeted Dual-Drug Silica Nanoformulations for Theragnostics (Small 22/2012)

Authors

  • Srivani Veeranarayanan,

    1. Bio Nano Electronics Research Center, Graduate School of Interdisciplinary New Science, Toyo University, Kawagoe, Saitama 350-8585, Japan
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  • Aby Cheruvathoor Poulose,

    1. Bio Nano Electronics Research Center, Graduate School of Interdisciplinary New Science, Toyo University, Kawagoe, Saitama 350-8585, Japan
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  • M. Sheikh Mohamed,

    1. Bio Nano Electronics Research Center, Graduate School of Interdisciplinary New Science, Toyo University, Kawagoe, Saitama 350-8585, Japan
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  • Saino Hanna Varghese,

    1. Bio Nano Electronics Research Center, Graduate School of Interdisciplinary New Science, Toyo University, Kawagoe, Saitama 350-8585, Japan
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  • Yutaka Nagaoka,

    1. Bio Nano Electronics Research Center, Graduate School of Interdisciplinary New Science, Toyo University, Kawagoe, Saitama 350-8585, Japan
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  • Yasuhiko Yoshida,

    1. Bio Nano Electronics Research Center, Graduate School of Interdisciplinary New Science, Toyo University, Kawagoe, Saitama 350-8585, Japan
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  • Toru Maekawa,

    1. Bio Nano Electronics Research Center, Graduate School of Interdisciplinary New Science, Toyo University, Kawagoe, Saitama 350-8585, Japan
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  • D. Sakthi Kumar

    Corresponding author
    1. Bio Nano Electronics Research Center, Graduate School of Interdisciplinary New Science, Toyo University, Kawagoe, Saitama 350-8585, Japan
    • Bio Nano Electronics Research Center, Graduate School of Interdisciplinary New Science, Toyo University, Kawagoe, Saitama 350-8585, Japan.
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Abstract

original image

A silica nanoparticle-based drug-delivery system developed by D. S. Kumar and co-workers for transporting multiple drugs and imaging agents is armed with tripletargeting ligands, which home in on cancer and angiogenic cells in a collegial fashion. This high-precision, multi-target concept described on page 3476 culminates in an effective therapeutic nanoformulation against breast cancer cells, completely disabling the migration and angiogenic sprouting abilities of activated endothelial cells, achieving both anti-cancer and anti-angiogenic potential in a singular lethal form. This nanoscheme could become the paragon for future cancer/angiogenesis treatment strategies.

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