3D Nanofabrication: 3D Nanofabrication of Fluidic Components by Corner Lithography (Small 24/2012)

Authors

  • Erwin J. W. Berenschot,

    1. Transducers Science and Technology Group, MESA+ Institute for Nanotechnology, University of Twente, P. O. Box 217, 7500 AE Enschede, The Netherlands
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  • Narges Burouni,

    1. Transducers Science and Technology Group, MESA+ Institute for Nanotechnology, University of Twente, P. O. Box 217, 7500 AE Enschede, The Netherlands
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  • Bart Schurink,

    1. Tissue Regeneration Group, MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, P. O. Box 217, 7500 AE Enschede, The Netherlands
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  • Joost W. van Honschoten,

    1. Transducers Science and Technology Group, MESA+ Institute for Nanotechnology, University of Twente, P. O. Box 217, 7500 AE Enschede, The Netherlands
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  • Remco G. P. Sanders,

    1. Transducers Science and Technology Group, MESA+ Institute for Nanotechnology, University of Twente, P. O. Box 217, 7500 AE Enschede, The Netherlands
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  • Roman Truckenmuller,

    1. Tissue Regeneration Group, MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, P. O. Box 217, 7500 AE Enschede, The Netherlands
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  • Henri V. Jansen,

    1. Transducers Science and Technology Group, MESA+ Institute for Nanotechnology, University of Twente, P. O. Box 217, 7500 AE Enschede, The Netherlands
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  • Miko C. Elwenspoek,

    1. Transducers Science and Technology Group, MESA+ Institute for Nanotechnology, University of Twente, P. O. Box 217, 7500 AE Enschede, The Netherlands
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  • Aart A. van Apeldoorn,

    1. Tissue Regeneration Group, MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, P. O. Box 217, 7500 AE Enschede, The Netherlands
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  • Niels R. Tas

    Corresponding author
    1. Transducers Science and Technology Group, MESA+ Institute for Nanotechnology, University of Twente, P. O. Box 217, 7500 AE Enschede, The Netherlands
    • Transducers Science and Technology Group, MESA+ Institute for Nanotechnology, University of Twente, P. O. Box 217, 7500 AE Enschede, The Netherlands.
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  • Dr. Joost W. van Honschoten is deceased, as of January 12th, 2011.

Abstract

original image

A pyramid microarray comprising microsized nanowires made by 3D corner lithography is presented by N. R. Tas and co-workers on page 3823. The arrays are integrated into a cell-seeding device for the entrapment of single cells. Polystyrene microspheres are shown efficiently captured from a suspension of homogeneously shaped spheres. The same procedure is done with a suspension of primary bovine chondrocytes, after which their phenotype is studied over 48 h. The magnified electron micrograph shows the efficient entrapment of 1 cell per pyramid after 2 h of cell culture. Cells maintain their native round morphology during entrapment, while the onset of protein deposition starts between these confined cells.

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