Serrs: Plasmonic Nanostructures for SERRS Multiplexed Identification of Tumor-Associated Antigens (Small 24/2012)

Authors

  • Moreno Meneghetti,

    Corresponding author
    1. Department of Chemical Sciences, Unibversity of Padova, Via Marzolo, 1, 35131 Padova, Italy
    • Moreno Meneghetti, Department of Chemical Sciences, Unibversity of Padova, Via Marzolo, 1, 35131 Padova, Italy

      Marco Colombatti, Department of Pathology and Diagnostics, Section of Immunology, University of Verona, c/o Policlinico GB Rossi, Piazz.le LA Scuro 10, 37134 Verona, Italy.

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  • Alessia Scarsi,

    1. Department of Chemical Sciences, Unibversity of Padova, Via Marzolo, 1, 35131 Padova, Italy
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  • Lucio Litti,

    1. Department of Chemical Sciences, Unibversity of Padova, Via Marzolo, 1, 35131 Padova, Italy
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  • Gabriele Marcolongo,

    1. Department of Chemical Sciences, Unibversity of Padova, Via Marzolo, 1, 35131 Padova, Italy
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  • Vincenzo Amendola,

    1. Department of Chemical Sciences, Unibversity of Padova, Via Marzolo, 1, 35131 Padova, Italy
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  • Marina Gobbo,

    1. Department of Chemical Sciences, Unibversity of Padova, Via Marzolo, 1, 35131 Padova, Italy
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  • Marzia Di Chio,

    1. Department of Public Health and Community Medicine, University of Verona, c/o Policlinico GB Rossi, Piazz.le LA Scuro 10, 37134 Verona, Italy
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  • Anita Boscaini,

    1. Department of Pathology and Diagnostics, Section of Immunology, University of Verona, c/o Policlinico GB Rossi, Piazz.le LA Scuro 10, 37134 Verona, Italy
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  • Giulio Fracasso,

    1. Department of Pathology and Diagnostics, Section of Immunology, University of Verona, c/o Policlinico GB Rossi, Piazz.le LA Scuro 10, 37134 Verona, Italy
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  • Marco Colombatti

    Corresponding author
    1. Department of Pathology and Diagnostics, Section of Immunology, University of Verona, c/o Policlinico GB Rossi, Piazz.le LA Scuro 10, 37134 Verona, Italy
    • Moreno Meneghetti, Department of Chemical Sciences, Unibversity of Padova, Via Marzolo, 1, 35131 Padova, Italy

      Marco Colombatti, Department of Pathology and Diagnostics, Section of Immunology, University of Verona, c/o Policlinico GB Rossi, Piazz.le LA Scuro 10, 37134 Verona, Italy.

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Abstract

original image

Gold nanostructures, obtained by centrifugal aggregation of nanoparticles synthesized by laser ablation in solution, are functionalized with different SERRS reporters and with different associated antibodies by M. Meneghetti, M. Colombatti and co-workers on page 3733. Prostatic cancer cells expressing one of two antigens (PSMA or PSCA) or both are targeted by specific antibodies and are easily recognized in SERRS spectra of the reporters associated to the antibodies. The presence of both antigens is recognized on the same cell with only one spectrum, realizing SERRS multiplexing.

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