Exhaustion of Racing Sperm in Nature-Mimicking Microfluidic Channels During Sorting

Authors

  • Savas Tasoglu,

    1. Bio-Acoustic-MEMS in Medicine (BAMM) Laboratory, Center for Bioengineering, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA
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  • Hooman Safaee,

    1. Bio-Acoustic-MEMS in Medicine (BAMM) Laboratory, Center for Bioengineering, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA
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  • Xiaohui Zhang,

    1. Bio-Acoustic-MEMS in Medicine (BAMM) Laboratory, Center for Bioengineering, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA
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  • James L. Kingsley,

    1. Department of Physics, Worcester Polytechnic Institute, Worcester, MA, USA
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  • Paolo N. Catalano,

    1. Bio-Acoustic-MEMS in Medicine (BAMM) Laboratory, Center for Bioengineering, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA
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  • Umut Atakan Gurkan,

    1. Bio-Acoustic-MEMS in Medicine (BAMM) Laboratory, Center for Bioengineering, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA
    Current affiliation:
    1. Case Biomanufacturing and Microfabrication Laboratory, Mechanical and Aerospace Engineering, Case Western Reserve University, Advanced Platform Technology Center, Louis Stokes Cleveland Veterans Affairs Medical Center, Cleveland, OH, USA
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  • Aida Nureddin,

    1. Bio-Acoustic-MEMS in Medicine (BAMM) Laboratory, Center for Bioengineering, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA
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  • Emre Kayaalp,

    1. Jamaica Hospital Medical Center, Department of Obstetrics and Gynecology, Queens, NY, USA
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  • Raymond M. Anchan,

    1. Center for Infertility and Reproductive Surgery, Obstetrics Gynecology and Reproductive Biology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA
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  • Richard L. Maas,

    1. Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA
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  • Erkan Tüzel,

    Corresponding author
    1. Department of Physics, Biomedical Engineering and Computer Science, Worcester Polytechnic Institute, Worcester, MA, USA
    • Erkan Tüzel, Department of Physics, Biomedical Engineering and Computer Science, Worcester Polytechnic Institute, Worcester, MA, USA.

      Utkan Demirci, Bio-Acoustic-MEMS in Medicine (BAMM) Laboratory, Center for Bioengineering, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA

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  • Utkan Demirci

    Corresponding author
    1. Bio-Acoustic-MEMS in Medicine (BAMM) Laboratory, Center for Bioengineering, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA
    2. Harvard-Massachusetts Institute of Technology Health Sciences and Technology, Cambridge, MA, USA
    • Erkan Tüzel, Department of Physics, Biomedical Engineering and Computer Science, Worcester Polytechnic Institute, Worcester, MA, USA.

      Utkan Demirci, Bio-Acoustic-MEMS in Medicine (BAMM) Laboratory, Center for Bioengineering, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA

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Abstract

original image

Fertilization is central to the survival and propagation of a species, however, the precise mechanisms that regulate the sperm's journey to the egg are not well understood. In nature, the sperm has to swim through the cervical mucus, akin to a microfluidic channel. Inspired by this, a simple, cost-effective microfluidic channel is designed on the same scale. The experimental results are supported by a computational model incorporating the exhaustion time of sperm.

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