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Pericytes, Stem-Cell-Like Cells, but not Mesenchymal Stem Cells are Recruited to Support Microvascular Tube Stabilization

Authors

  • Omar F. Zouani,

    Corresponding author
    1. Université Bordeaux 1-CNRS, UMR5248, Institut Européen de Chimie et Biologie, 2, rue Robert Escarpit, F-33607 Pessac, France
    • Université Bordeaux 1-CNRS, UMR5248, Institut Européen de Chimie et Biologie, 2, rue Robert Escarpit, F-33607 Pessac, France.
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  • Yifeng Lei,

    1. Université Bordeaux 1-CNRS, UMR5248, Institut Européen de Chimie et Biologie, 2, rue Robert Escarpit, F-33607 Pessac, France
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  • Marie-Christine Durrieu

    1. Université Bordeaux 1-CNRS, UMR5248, Institut Européen de Chimie et Biologie, 2, rue Robert Escarpit, F-33607 Pessac, France
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Abstract

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An experimental model is introduced for the induction of endothelial cell (EC) tubulogenesis after 24 h of incubation on micropatterned polymer surfaces. Pericytes or mesenchymal stem cells are added separately to this system to evaluate their effect on tubular stabilization. In the absence of additional cells, the tubular structures are lost after 36 h. Addition of only pericytes, however, stabilizes the EC vasculogenic tubes.

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