Bioinspired Patterning with Extreme Wettability Contrast on TiO2 Nanotube Array Surface: A Versatile Platform for Biomedical Applications

Authors

  • Yuekun Lai,

    Corresponding author
    1. Physikalisches Institute and Center for Nanotechnology (CeNTech), Westfälische Wilhelms-Universität Münster, Münster D-48149, Germany
    2. National Engineering Laboratory of Modern Silk, College of Textile and Clothing Engineering, Soochow University, Suzhou 215123, PR China
    • National Engineering Laboratory of Modern Silk, College of Textile and Clothing Engineering, Soochow University, Suzhou 215123, PR China
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  • Longxiang Lin,

    1. State Key Laboratory of Physical, Chemistry of Solid Surfaces, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, PR China
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  • Fei Pan,

    1. Physikalisches Institute and Center for Nanotechnology (CeNTech), Westfälische Wilhelms-Universität Münster, Münster D-48149, Germany
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  • Jianying Huang,

    1. National Engineering Laboratory of Modern Silk, College of Textile and Clothing Engineering, Soochow University, Suzhou 215123, PR China
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  • Ran Song,

    1. State Key Laboratory of Physical, Chemistry of Solid Surfaces, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, PR China
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  • Yongxia Huang,

    1. State Key Laboratory of Physical, Chemistry of Solid Surfaces, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, PR China
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  • Changjian Lin,

    Corresponding author
    1. State Key Laboratory of Physical, Chemistry of Solid Surfaces, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, PR China
    • State Key Laboratory of Physical, Chemistry of Solid Surfaces, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, PR China.
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  • Harald Fuchs,

    1. Physikalisches Institute and Center for Nanotechnology (CeNTech), Westfälische Wilhelms-Universität Münster, Münster D-48149, Germany
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  • Lifeng Chi

    Corresponding author
    1. Physikalisches Institute and Center for Nanotechnology (CeNTech), Westfälische Wilhelms-Universität Münster, Münster D-48149, Germany
    2. Institute of Functional Nano & Soft Materials (FUNSOM), Soochow University, Suzhou 215123, PR China
    • Physikalisches Institute and Center for Nanotechnology (CeNTech), Westfälische Wilhelms-Universität Münster, Münster D-48149, Germany
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Abstract

Binary wettability patterned surfaces with extremely high wetting contrasts can be found in nature on living creatures. They offer a versatile platform for microfluidic management. In this work, a facile approach to fabricating erasable and rewritable surface patterns with extreme wettability contrasts (superhydrophilic/superhydrophobic) on a TiO2 nanotube array (TNA) surface through self-assembly and photocatalytic lithography is reported. The multifunctional micropatterned superhydrophobic TNA surface can act as a 2D scaffold for site-selective cell immobilization and reversible protein absorption. Most importantly, such a high-contrast wettability template can be used to construct various well-defined 3D functional patterns, such as calcium phosphate, silver nanoparticles, drugs, and biomolecules in a highly selective manner. The 3D functional patterns would be a versatile platform in a wide range of applications, especial for biomedical devices (e.g., high-throughput molecular sensing, targeted antibacterials, and drug delivery). In a proof-of-concept study, the surface-enhanced Raman scattering and antibacterial performance of the fabricated 3D AgNP@TNA pattern, and the targeted drug delivery for site-specific and high-sensitivity cancer cell assays was investigated.

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